Article Details the Use of Multimeric Oligonucleotides to Improve Intracellular Conjugate Delivery
DENVER, CO, US – 2 October 2019 – World technology licensing leader MPEG LA today announced publication of a peer reviewed article in the October 2019 issue of Nucleic Acid Therapeutics on MPEG LA’s proprietary Increscent Therapeutics™ ligand-directed multiple payload oligonucleotide delivery platform.
“MPEG LA is proud to chart new territory with its development of a technology platform enabling drug developers to use oligonucleotide therapies to address new targets including cancer and those affecting the central nervous system,” said MPEG LA President and CEO Larry Horn.
According to principal author and innovator Dr. Jonathan Miles Brown, “the article concludes that delivery of multimeric oligonucleotide therapeutic agents to modulate gene expression or translation using MPEG LA’s Increscent Therapeutics™ may be of critical importance for effectively targeting cell/receptor types where ligand affinity, receptor copy number, or internalization rates are insufficient, as well as diseases where knockdowns of multiple genes or pathways are required.”
“In a departure from MPEG LA’s traditional pool licensing model that revolutionized licensing in the consumer electronics industry, MPEG LA’s Increscent Therapeutics™ platform is available for exclusive or nonexclusive licensing to the biopharma industry and poised to unlock and advance new healthcare opportunities,” said Kristin Neuman, MPEG LA’s Executive Director, Biotechnology Licensing.
An on-line version of the Nucleic Acid Therapeutics article “Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing” by Jonathan M. Brown, James E. Dahlman, Kristin K. Neuman, Carla A.H. Prata, Monika C. Krampert, Philipp M. Hadwiger and Hans-Peter Vornlocher may be found here.
Additional information about MPEG LA’s Increscent Therapeutics™ platform may be found here.